The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell-attracting Cytokines

Jumonji domain-containing protein 3 (JMJD3/KDM6B) demethylates lysine 27 on histone H3 (H3K27me3), a repressive epigenetic mark controlling chromatin organization and cellular senescence. To better understand the functional consequences of JMJD3 its expression was investigated in brain tumor cells....

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Publicat a:Mol Cancer Res
Autors principals: Perrigue, Patrick M., Silva, Michael E., Warden, Charles D., Feng, Nathan L., Reid, Michael A., Mota, Daniel J., Joseph, Lauren P., Tian, Yangzi Isabel, Glackin, Carlotta A., Gutova, Margarita, Najbauer, Joseph, Aboody, Karen S., Barish, Michael E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844544/
https://ncbi.nlm.nih.gov/pubmed/25652587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0268
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