Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

Recombinant soluble CD4 (rsCD4) has potent antiviral activity against cell line-adapted isolates of the human immunodeficiency virus type 1 (HIV-1) but low activity toward HIV-1 primary isolates from patients. A simple hypothesis proposed to explain this discrepancy, which questions the therapeutic...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Turner, S, Tizard, R, DeMarinis, J, Pepinsky, R B, Zullo, J, Schooley, R, Fisher, R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48444/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1741386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.4.1335
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