Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes

Folate deficiency during early embryonic development constitutes a risk factor for neural tube defects and potentially for childhood leukemia via unknown mechanisms. We tested whether folate consumption during the 12 months prior to conception induced DNA methylation modifications at birth in health...

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Udgivet i:Epigenetics
Main Authors: Gonseth, Semira, Roy, Ritu, Houseman, E Andres, de Smith, Adam J, Zhou, Mi, Lee, Seung-Tae, Nusslé, Sébastien, Singer, Amanda W, Wrensch, Margaret R, Metayer, Catherine, Wiemels, Joseph L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844202/
https://ncbi.nlm.nih.gov/pubmed/26646725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1117889
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