Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its releva...

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Publicat a:Leukemia
Autors principals: Jaako, P, Debnath, S, Olsson, K, Zhang, Y, Flygare, J, Lindström, MS, Bryder, D, Karlsson, S
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844018/
https://ncbi.nlm.nih.gov/pubmed/25987256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.128
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