A heterochronic genetic change from an EGFR mutation to an ALK rearrangement in a patient with lung adenocarcinoma: a case report

An 87-year-old man with postoperative recurrent lung adenocarcinoma was treated with gefitinib. At the beginning of treatment, surgically resected archived tumor tissue revealed a deletion in exon 19 of the EGFR gene, but no ALK gene rearrangement. After gefitinib treatment for 9 months, the disease...

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Detalhes bibliográficos
Publicado no:J Thorac Dis
Main Authors: Shiroyama, Takayuki, Tamiya, Motohiro, Hayama, Manabu, Nishihara, Takashi, Nishida, Takuji, Tanaka, Ayako, Morishita, Naoko, Suzuki, Hidekazu, Okamoto, Norio, Kawahara, Kunimitsu, Hirashima, Tomonori
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2016
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842787/
https://ncbi.nlm.nih.gov/pubmed/27162697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2016.03.43
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