Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization

There is growing evidence that defective DNA repair in neurons with accumulation of DNA lesions and loss of genome integrity underlies aging and many neurodegenerative disorders. An important challenge is to understand how neurons can tolerate the accumulation of persistent DNA lesions without trigg...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Mata-Garrido, Jorge, Casafont, Iñigo, Tapia, Olga, Berciano, Maria T., Lafarga, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840862/
https://ncbi.nlm.nih.gov/pubmed/27102221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0312-9
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