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Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs

Fifteen different ligands, including heparin (Hep), are cleared from lymph and blood by the Hyaluronan (HA) Receptor for Endocytosis (HARE; derived from Stabilin-2 by proteolysis), which contains four endocytic motifs (M1-M4). Endocytosis of HARE•Hep complexes is targeted to coated pits by M1, M2, a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pandey, Madhu S., Miller, Colton M., Harris, Edward N., Weigel, Paul H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839745/
https://ncbi.nlm.nih.gov/pubmed/27100626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154124
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