Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis

AIM: β-catenin signaling is a major oncogenic pathway in hepatocellular carcinoma (HCC). Since β-catenin phosphorylation by glycogen synthase kinase 3β (GSK3β) and casein kinase 1ε (CK1ε) results in its degradation, mutations affecting these phosphorylation sites cause β-catenin stabilization. Howev...

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Udgivet i:PLoS One
Main Authors: Okabe, Hirohisa, Kinoshita, Hiroki, Imai, Katsunori, Nakagawa, Shigeki, Higashi, Takaaki, Arima, Kota, Uchiyama, Hideaki, Ikegami, Toru, Harimoto, Norifumi, Itoh, Shinji, Ishiko, Takatoshi, Yoshizumi, Tomoharu, Beppu, Toru, Monga, Satdarshan P. S., Baba, Hideo, Maehara, Yoshihiko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839611/
https://ncbi.nlm.nih.gov/pubmed/27100093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152695
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