Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans

Processing of pre-mRNA into mRNA is an important regulatory mechanism in eukaryotes that is mediated by the spliceosome, a huge and dynamic ribonucleoprotein complex. Splicing defects are implicated in a spectrum of human disease, but the underlying mechanistic links remain largely unresolved. Using...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wu, Hao, Sun, Liwei, Wen, Yang, Liu, Yujuan, Yu, Jun, Mao, Feiyu, Wang, Ya, Tong, Chao, Guo, Xuejiang, Hu, Zhibin, Sha, Jiahao, Liu, Mingxi, Xia, Laixin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839444/
https://ncbi.nlm.nih.gov/pubmed/27035939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513682113
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