Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is highly infiltrated by CD4(+)T cells that express RORγt and IL-17 (T(H)17). Compelling evidence from the tumor microenvironment suggest that regulatory T cells (T(reg)) contribute to T(H)17 mediated inflammation. Concurrently, PDAC patients have elevated lev...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Chellappa, Stalin, Hugenschmidt, Harald, Hagness, Morten, Line, Pål D., Labori, Knut J., Wiedswang, Gro, Taskén, Kjetil, Aandahl, Einar M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839385/
https://ncbi.nlm.nih.gov/pubmed/27141387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1102828
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