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Overexpression of KIR inhibitory ligands (HLA-I) determines that immunosurveillance of myeloma depends on diverse and strong NK cell licensing

Missing self recognition makes cancer sensitive to natural killer cell (NKc) reactivity. However, this model disregards the NKc licensing effect, which highly increases NKc reactivity through interactions of inhibitory killer cell immunoglobulin-like receptors (iKIR) with their cognate HLA-I ligands...

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Foilsithe in:Oncoimmunology
Main Authors: Martínez-Sánchez, María V., Periago, Adela, Legaz, Isabel, Gimeno, Lourdes, Mrowiec, Anna, Montes-Barqueros, Natividad R., Campillo, José A., Bolarin, José M., Bernardo, María V., López-Álvarez, María R., González, Consuelo, García-Garay, María C., Muro, Manuel, Cabañas-Perianes, Valentin, Fuster, Jose L., García-Alonso, Ana M., Moraleda, José M., Álvarez-Lopez, María R., Minguela, Alfredo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839374/
https://ncbi.nlm.nih.gov/pubmed/27141379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1093721
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