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Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients

Thymidylate synthase (TS) is a tumor-associated enzyme critical for DNA replication and main 5′-fluorouracil (5′-FU) target. TSPP/VAC1 is a multi-arm trial phase-Ib trial program aimed to investigate the toxicity and biomodulatory activity of a poly-epitope-peptide vaccine to TS (TSPP) in cancer pat...

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Bibliografski detalji
Izdano u:Oncoimmunology
Glavni autori: Correale, Pierpaolo, Botta, Cirino, Martino, Elodia Claudio, Ulivieri, Cristina, Battaglia, Giuseppe, Carfagno, Tommaso, Rossetti, Maria Grazia, Fioravanti, Antonella, Guidelli, Giacomo Maria, Cheleschi, Sara, Gandolfo, Claudia, Carbone, Francesco, Baldari, Tatiana Cosima, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Pirtoli, Luigi, Cusi, Maria Grazia
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839351/
https://ncbi.nlm.nih.gov/pubmed/27141384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1101205
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