Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion

It is increasingly recognized that trastuzumab, an antibody approved for treating human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, exerts some of its antitumor effects through enhanced T cell responses. Full activation of CD8(+) T cells requires both expression of major...

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Detaylı Bibliyografya
Yayımlandı:Oncoimmunology
Asıl Yazarlar: Chaganty, Bharat K. R., Lu, Yang, Qiu, Songbo, Somanchi, Srinivas S., Lee, Dean A., Fan, Zhen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2015
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839349/
https://ncbi.nlm.nih.gov/pubmed/27141382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1100790
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