CD8 engineered cytotoxic T cells reprogram melanoma tumor environment

Cytotoxic T lymphocytes (CTL) from CD8β-deficient mice have powerful FasL-mediated cytotoxicity and IFNγ responses, but ablated Ca(2+) and NFAT signaling, which can be restored by transduction with CD8β. Upon infection with lymphocytic choriomeningitis virus (LCMV), these cells yielded GP33-specific...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncoimmunology
Egile Nagusiak: Leignadier, Julie, Favre, Stephanie, Luther, Sanjiv A., Luescher, Immanuel F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2015
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839323/
https://ncbi.nlm.nih.gov/pubmed/27141342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1086861
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