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CD8 engineered cytotoxic T cells reprogram melanoma tumor environment
Cytotoxic T lymphocytes (CTL) from CD8β-deficient mice have powerful FasL-mediated cytotoxicity and IFNγ responses, but ablated Ca(2+) and NFAT signaling, which can be restored by transduction with CD8β. Upon infection with lymphocytic choriomeningitis virus (LCMV), these cells yielded GP33-specific...
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| Publicat a: | Oncoimmunology |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4839323/ https://ncbi.nlm.nih.gov/pubmed/27141342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1086861 |
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