Expression-Based Genome-Wide Association Study Links Vitamin D–Binding Protein With Autoantigenicity in Type 1 Diabetes

Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression in the thymus and pancreatic lymph nodes (PLN...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Kodama, Keiichi, Zhao, Zhiyuan, Toda, Kyoko, Yip, Linda, Fuhlbrigge, Rebecca, Miao, Dongmei, Fathman, C. Garrison, Yamada, Satoru, Butte, Atul J., Yu, Liping
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839207/
https://ncbi.nlm.nih.gov/pubmed/26983959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1308
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