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In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

BACKGROUND: The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the JNK pathway in cultured rat retinal ganglion cell (RGC) death and in mouse retinal ischemia/reperfusion (I/R) injury of the visual...

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Publicado en:Mol Neurodegener
Main Authors: Kim, Byung-Jin, Silverman, Sean M., Liu, Yang, Wordinger, Robert J., Pang, Iok-Hou, Clark, Abbot F.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839164/
https://ncbi.nlm.nih.gov/pubmed/27098079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0093-4
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