Multicentre open-label randomised controlled trial to compare colistin alone with colistin plus meropenem for the treatment of severe infections caused by carbapenem-resistant Gram-negative infections (AIDA): a study protocol

INTRODUCTION: The emergence of antibiotic-resistant bacteria has driven renewed interest in older antibacterials, including colistin. Previous studies have shown that colistin is less effective and more toxic than modern antibiotics. In vitro synergy studies and clinical observational studies sugges...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Dickstein, Yaakov, Leibovici, Leonard, Yahav, Dafna, Eliakim-Raz, Noa, Daikos, George L, Skiada, Anna, Antoniadou, Anastasia, Carmeli, Yehuda, Nutman, Amir, Levi, Inbar, Adler, Amos, Durante-Mangoni, Emanuele, Andini, Roberto, Cavezza, Giusi, Mouton, Johan W, Wijma, Rixt A, Theuretzbacher, Ursula, Friberg, Lena E, Kristoffersson, Anders N, Zusman, Oren, Koppel, Fidi, Dishon Benattar, Yael, Altunin, Sergey, Paul, Mical
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Infectious Diseases
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838684/
https://ncbi.nlm.nih.gov/pubmed/27098822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2015-009956
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