Investigating the Implications of a Variable RBE on Proton Dose Fractionation Across a Clinical Pencil Beam Scanned Spread-Out Bragg Peak

PURPOSE: To investigate the clinical implications of a variable relative biological effectiveness (RBE) on proton dose fractionation. Using acute exposures, the current clinical adoption of a generic, constant cell killing RBE has been shown to underestimate the effect of the sharp increase in linea...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Marshall, Thomas I., Chaudhary, Pankaj, Michaelidesová, Anna, Vachelová, Jana, Davídková, Marie, Vondráček, Vladimir, Schettino, Giuseppe, Prise, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Inc 2016
Assuntos:
RBE and Particle Therapy Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838672/
https://ncbi.nlm.nih.gov/pubmed/27084630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2016.02.029
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