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SCO2 mediates oxidative stress-induced glycolysis to OXPHOS switch in hematopoietic stem cells
Fanconi anemia (FA) is an inherited bone marrow (BM) failure syndrome, presumably resulting from defects in hematopoietic stem cells (HSCs). Normal HSCs depend more on glycolysis than on oxidative phosphorylation (OXPHOS) for energy production. Here we show that FA HSCs are more sensitive to the res...
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| Publicado no: | Stem Cells |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838537/ https://ncbi.nlm.nih.gov/pubmed/26676373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2260 |
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