Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies

Cerebral Cavernous Malformation (CCM) is a major cerebrovascular disease of proven genetic origin affecting 0.3–0.5% of the general population. It is characterized by abnormally enlarged and leaky capillaries, which predispose to seizures, focal neurological deficits and intracerebral hemorrhage. Ca...

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Publicado en:Rare Dis
Autores principales: Marchi, Saverio, Trapani, Eliana, Corricelli, Mariangela, Goitre, Luca, Pinton, Paolo, Retta, Saverio Francesco
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838318/
https://ncbi.nlm.nih.gov/pubmed/27141412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21675511.2016.1142640
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