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Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature translation termination for rapid degradation. From yeasts to humans, activation of NMD requires the function of the three conserved Upf factors...
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| Publicado en: | Annu Rev Genet |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4837945/ https://ncbi.nlm.nih.gov/pubmed/26436458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-genet-112414-054639 |
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