Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

OBJECTIVE: The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was t...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Boothe, Tobias, Lim, Gareth E., Cen, Haoning, Skovsø, Søs, Piske, Micah, Li, Shu Nan, Nabi, Ivan R., Gilon, Patrick, Johnson, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837300/
https://ncbi.nlm.nih.gov/pubmed/27110488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.01.009
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