Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis

BACKGROUND: Deficits in working memory (WM) are a core feature of schizophrenia (SZ) and other psychotic disorders. We examined brain activity during WM in persons at clinical high risk (CHR) for psychosis. METHODS: Thirty-seven CHR and 34 healthy control participants underwent functional MRI (fMRI)...

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Pubblicato in:Schizophr Res
Autori principali: Thermenos, Heidi W., Juelich, Richard J., DiChiara, Samantha R., Mesholam-Gately, Raquelle I., Woodberry, Kristen A., Wojcik, Joanne, Makris, Nikos, Keshavan, Matcheri S., Whitfield-Gabrieli, Susan, Woo, Tsung-Ung W., Petryshen, Tracey L., Goldstein, Jill M., Shenton, Martha E., McCarley, Robert W., Seidman, Larry J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836956/
https://ncbi.nlm.nih.gov/pubmed/26965745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.schres.2016.02.023
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