A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

OBJECTIVE: To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS). METHODS: Sixty participants with SALS from 10 centers were randomized 1:1:1 to placebo, mexiletine 300 mg/d, or mexiletine 900 mg...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Weiss, Michael D., Macklin, Eric A., Simmons, Zachary, Knox, Angela S., Greenblatt, David J., Atassi, Nazem, Graves, Michael, Parziale, Nicholas, Salameh, Johnny S., Quinn, Colin, Brown, Robert H., Distad, Jane B., Trivedi, Jaya, Shefner, Jeremy M., Barohn, Richard J., Pestronk, Alan, Swenson, Andrea, Cudkowicz, Merit E.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836879/
https://ncbi.nlm.nih.gov/pubmed/26911633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000002507
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