Deletions linked to TP53 loss drive cancer through p53–independent mechanisms

Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in human cancer and typically occur through a two-hit mechanism involving a missense mutation in one allele and a ‘loss of heterozygosity’ deletion encompassing the other. While TP53 missense mutations can also co...

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Publicado no:Nature
Main Authors: Liu, Yu, Chen, Chong, Xu, Zhengmin, Scuoppo, Claudio, Rillahan, Cory D., Gao, Jianjiong, Spitzer, Barbara, Bosbach, Benedikt, Kastenhuber, Edward R., Baslan, Timour, Ackermann, Sarah, Cheng, Lihua, Wang, Qingguo, Niu, Ting, Schultz, Nikolaus, Levine, Ross L., Mills, Alea A., Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836395/
https://ncbi.nlm.nih.gov/pubmed/26982726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17157
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