Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides

Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2′-fucosyllactose (2′FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2′FL and 3FL bound at the equivale...

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Vydáno v:J Virol
Hlavní autoři: Weichert, Stefan, Koromyslova, Anna, Singh, Bishal K., Hansman, Satoko, Jennewein, Stefan, Schroten, Horst, Hansman, Grant S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836343/
https://ncbi.nlm.nih.gov/pubmed/26889023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03223-15
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