Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins

Autophagy is activated early after human cytomegalovirus (HCMV) infection but, later on, the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 and IRS1, which inhibit autophagy during infection. Expression of either TRS1 or IRS1 was able to block autophagy in different cell lines,...

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Vydáno v:Autophagy
Hlavní autoři: Mouna, Lina, Hernandez, Eva, Bonte, Dorine, Brost, Rebekka, Amazit, Larbi, Delgui, Laura R., Brune, Wolfram, Geballe, Adam P., Beau, Isabelle, Esclatine, Audrey
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Basic Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836022/
https://ncbi.nlm.nih.gov/pubmed/26654401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1125071
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