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Mechanism of action of the tuberculosis and Crohn disease risk factor IRGM in autophagy

Polymorphisms in the IRGM gene, associated with Crohn disease (CD) and tuberculosis, are among the earliest identified examples documenting the role of autophagy in human disease. Functional studies have shown that IRGM protects against these diseases by modulating autophagy, yet the exact molecular...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Chauhan, Santosh, Mandell, Michael A., Deretic, Vojo
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835981/
https://ncbi.nlm.nih.gov/pubmed/26313894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1084457
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