Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses

BACKGROUND: Japanese encephalitis (JE), a leading cause of viral encephalitis, is characterized by extensive neuroinflammation following infection with neurotropic JE virus (JEV). Indoleamine 2,3-dioxygenase (IDO) has been identified as an enzyme associated with immunoregulatory function. Although t...

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Publicado en:J Neuroinflammation
Autores principales: Kim, Seong Bum, Choi, Jin Young, Uyangaa, Erdenebileg, Patil, Ajit Mahadev, Hossain, Ferdaus Mohd Altaf, Hur, Jin, Park, Sang-Youel, Lee, John-Hwa, Kim, Koanhoi, Eo, Seong Kug
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835894/
https://ncbi.nlm.nih.gov/pubmed/27090635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0551-5
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