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A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia

Autosomal dominant omodysplasia is a rare skeletal dysplasia characterized by short humeri, radial head dislocation, short first metacarpals, facial dysmorphism and genitourinary anomalies. We performed next-generation whole-exome sequencing and comparative analysis of a proband with omodysplasia, h...

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Publicat a:Hum Mol Genet
Autors principals: Saal, Howard M., Prows, Cynthia A., Guerreiro, Iris, Donlin, Milene, Knudson, Luke, Sund, Kristen L., Chang, Ching-Fang, Brugmann, Samantha A., Stottmann, Rolf W.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834928/
https://ncbi.nlm.nih.gov/pubmed/25759469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv088
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