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Increased Olfactory Bulb BDNF Expression Does Not Rescue Deficits in Olfactory Neurogenesis in the Huntington’s Disease R6/2 Mouse

Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by expansion of CAG trinucleotide repeats in the huntingtin gene. Mutant huntingtin protein (mhtt) interferes with the actions of brain-derived neurotrophic factor (BDNF), and BDNF signaling is reduced in the diseased striat...

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Foilsithe in:Chem Senses
Main Authors: Smail, Shamayra, Bahga, Dalbir, McDole, Brittnee, Guthrie, Kathleen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834850/
https://ncbi.nlm.nih.gov/pubmed/26783111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/chemse/bjv076
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