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Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect

Several problems limit the application of gene transfer to correct the cystic fibrosis (CF) Cl(–) transport defect in airway epithelia. These include inefficient transduction with vectors applied to the apical surface, a low rate of division by airway epithelial cells, failure of transgene expressio...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Wang, Guoshun, Slepushkin, Vladimir, Zabner, Joseph, Keshavjee, Shaf, Johnston, Julie C., Sauter, Sybille L., Jolly, Doug J., Dubensky, Thomas W., Davidson, Beverly L., McCray, Paul B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1999
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Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC483477/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10587528/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8390
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