Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability

[Image: see text] Cannabidiol is the nonpsychoactive natural component of C. sativa that has been shown to be neuroprotective in multiple animal models. Our interest is to advance a therapeutic candidate for the orphan indication hepatic encephalopathy (HE). HE is a serious neurological disorder tha...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kinney, William A., McDonnell, Mark E., Zhong, Hua Marlon, Liu, Chaomin, Yang, Lanyi, Ling, Wei, Qian, Tao, Chen, Yu, Cai, Zhijie, Petkanas, Dean, Brenneman, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834656/
https://ncbi.nlm.nih.gov/pubmed/27096053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00009
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