Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice

Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive. Since obesity leads to chronic low-grade inflammation and affects metabolic signaling we hypothesized that postnatal hyperalimentation (pHA) induced by maternal high-fat-diet during lactation lea...

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Publicado no:Sci Rep
Main Authors: Dinger, Katharina, Kasper, Philipp, Hucklenbruch-Rother, Eva, Vohlen, Christina, Jobst, Eva, Janoschek, Ruth, Bae-Gartz, Inga, van Koningsbruggen-Rietschel, Silke, Plank, Christian, Dötsch, Jörg, Alejandre Alcázar, Miguel Angel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834579/
https://ncbi.nlm.nih.gov/pubmed/27087690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24168
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