R(+)-Baclofen, but Not S(−)-Baclofen, Alters Alcohol Self-Administration in Alcohol-Preferring Rats

Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several ­alcohol-motivated behaviors, including alcohol drinking and alcohol ­self-administration, in rats and mice. Recent data suggested that baclofen may have bidirectional, stereospecific effects, with the more active enant...

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Vydáno v:Front Psychiatry
Hlavní autoři: Lorrai, Irene, Maccioni, Paola, Gessa, Gian Luigi, Colombo, Giancarlo
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Psychiatry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834306/
https://ncbi.nlm.nih.gov/pubmed/27148096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2016.00068
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