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HDAC inhibitors cause site-specific chromatin remodeling at PU.1-bound enhancers in K562 cells

BACKGROUND: Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer agents for particular malignancies. However, clinical use is often confounded by toxicity, perhaps due to indiscriminate hyperacetylation of cellular proteins. Therefore, elucidating the mechanisms by wh...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Frank, Christopher L., Manandhar, Dinesh, Gordân, Raluca, Crawford, Gregory E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833939/
https://ncbi.nlm.nih.gov/pubmed/27087856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0065-5
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