sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Cancer is a disease of aging, and aged cancer patients have a poorer prognosis. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumor progression have been largely unexplored. Since dermal...

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Wydane w:Nature
Główni autorzy: Kaur, Amanpreet, Webster, Marie R., Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H., Dang, Vanessa M., Appleton, Jessica, O’Connell, Michael P., Cheng, Phil, Valiga, Alexander A., Morissette, Rachel, McDonnell, Nazli B., Ferrucci, Luigi, Kossenkov, Andrew V., Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H., Lehrmann, Elin, Becker, Kevin G., Flaherty, Keith T., Frederick, Dennie T., Wargo, Jennifer A., Cooper, Zachary A., Tetzlaff, Michael T., Hudgens, Courtney, Aird, Katherine M., Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S., Chan, Matthew, Menzies, Alexander M., Long, Georgina V., Johnson, Douglas B., Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W., Bosenberg, Marcus, Ribas, Antoni, Weeraratna, Ashani T.
Format: Artigo
Język:Inglês
Wydane: 2016
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833579/
https://ncbi.nlm.nih.gov/pubmed/27042933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17392
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