sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Cancer is a disease of aging, and aged cancer patients have a poorer prognosis. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumor progression have been largely unexplored. Since dermal...

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Gepubliceerd in:Nature
Hoofdauteurs: Kaur, Amanpreet, Webster, Marie R., Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H., Dang, Vanessa M., Appleton, Jessica, O’Connell, Michael P., Cheng, Phil, Valiga, Alexander A., Morissette, Rachel, McDonnell, Nazli B., Ferrucci, Luigi, Kossenkov, Andrew V., Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H., Lehrmann, Elin, Becker, Kevin G., Flaherty, Keith T., Frederick, Dennie T., Wargo, Jennifer A., Cooper, Zachary A., Tetzlaff, Michael T., Hudgens, Courtney, Aird, Katherine M., Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S., Chan, Matthew, Menzies, Alexander M., Long, Georgina V., Johnson, Douglas B., Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W., Bosenberg, Marcus, Ribas, Antoni, Weeraratna, Ashani T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833579/
https://ncbi.nlm.nih.gov/pubmed/27042933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17392
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