Leptin Mediate High Fat Diet Sensitization of Angiotensin II-elicited Hypertension by Upregulating the Brain Renin-Angiotensin System and Inflammation

Obesity is characterized by increased circulating levels of the adipocyte-derived hormone leptin, which can increase sympathetic nerve activity and raise blood pressure. A previous study revealed that rats fed a high fat diet (HFD) have an enhanced hypertensive response to subsequent angiotensin (An...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Xue, Baojian, Yu, Yang, Zhang, Zhongming, Guo, Fang, Beltz, Terry G., Thunhorst, Robert L., Felder, Robert B., Johnson, Alan Kim
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833570/
https://ncbi.nlm.nih.gov/pubmed/27021010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06736
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