Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray

The Smyd1 gene encodes a lysine methyltransferase specifically expressed in striated muscle. Because Smyd1-null mouse embryos die from heart malformation prior to formation of skeletal muscle, we developed a Smyd1 conditional-knockout allele to determine the consequence of SMYD1 loss in mammalian sk...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Stewart, M. David, Lopez, Suhujey, Nagandla, Harika, Soibam, Benjamin, Benham, Ashley, Nguyen, Jasmine, Valenzuela, Nicolas, Wu, Harry J., Burns, Alan R., Rasmussen, Tara L., Tucker, Haley O., Schwartz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833328/
https://ncbi.nlm.nih.gov/pubmed/26935107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022491
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