Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold protein that regulates signaling in multiple cell types. We found increased Cav-1 expression in human and murine T cells after allogeneic hematopoietic cell transplantation. Indeed, Cav-1(−/−) donor T cells caused less...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Schönle, Anne, Hartl, Frederike A., Mentzel, Jan, Nöltner, Theresa, Rauch, Katharina S., Prestipino, Alessandro, Wohlfeil, Sebastian A., Apostolova, Petya, Hechinger, Anne-Kathrin, Melchinger, Wolfgang, Fehrenbach, Kerstin, Guadamillas, Marta C., Follo, Marie, Prinz, Gabriele, Ruess, Ann-Katrin, Pfeifer, Dietmar, Angel del Pozo, Miguel, Schmitt-Graeff, Annette, Duyster, Justus, Hippen, Keli I., Blazar, Bruce R., Schachtrup, Kristina, Minguet, Susana, Zeiser, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832510/
https://ncbi.nlm.nih.gov/pubmed/26837700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-672428
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