Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1

BACKGROUND: Activation of NMDA receptors can induce iron movement into neurons by the small GTPase Dexras1 via the divalent metal transporter 1 (DMT1). This pathway under pathological conditions such as NMDA excitotoxicity contributes to metal-catalyzed reactive oxygen species (ROS) generation and n...

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Pubblicato in:Mol Brain
Autori principali: White, Rachel S., Bhattacharya, Anup K., Chen, Yong, Byrd, Madeleine, McMullen, Mary F., Siegel, Steven J., Carlson, Gregory C., Kim, Sangwon F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832449/
https://ncbi.nlm.nih.gov/pubmed/27080392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0220-8
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