Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass Cases

High bone mass (HBM) can be an incidental clinical finding; however, monogenic HBM disorders (eg, LRP5 or SOST mutations) are rare. We aimed to determine to what extent HBM is explained by mutations in known HBM genes. A total of 258 unrelated HBM cases were identified from a review of 335,115 DXA s...

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Publicado en:J Bone Miner Res
Main Authors: Gregson, Celia L, Wheeler, Lawrie, Hardcastle, Sarah A, Appleton, Louise H, Addison, Kathryn A, Brugmans, Marieke, Clark, Graeme R, Ward, Kate A, Paggiosi, Margaret, Stone, Mike, Thomas, Joegi, Agarwal, Rohan, Poole, Kenneth ES, McCloskey, Eugene, Fraser, William D, Williams, Eleanor, Bullock, Alex N, Davey Smith, George, Brown, Matthew A, Tobias, Jon H, Duncan, Emma L
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832273/
https://ncbi.nlm.nih.gov/pubmed/26348019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2706
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