Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in cancer angiogenesis. In this study, a series of novel furo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine based-derivatives were designed and synthesized as VEGFR-2 inhibitors, in accordance to the structure activity relat...

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Publicado no:Sci Rep
Main Authors: Aziz, Marwa A., Serya, Rabah A. T., Lasheen, Deena S., Abdel-Aziz, Amal Kamal, Esmat, Ahmed, Mansour, Ahmed M., Singab, Abdel Nasser B., Abouzid, Khaled A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832243/
https://ncbi.nlm.nih.gov/pubmed/27080011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24460
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