Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience

Rats that have self-administered methamphetamine (meth) under long access, but not short access, conditions do not recognize novel objects. The perirhinal cortex is critical for novelty detection, and perirhinal metabotropic glutamate 5 receptors (mGlu5) are downregulated after long-access meth. The...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuropsychopharmacology
Main Authors: Peters, Jamie, Scofield, Michael D, Ghee, Shannon M, Heinsbroek, Jasper A, Reichel, Carmela M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832007/
https://ncbi.nlm.nih.gov/pubmed/26365953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.283
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