Assessment of Tumor Heterogeneity, as Evidenced by Gene Expression Profiles, Pathway Activation, and Gene Copy Number, in Patients with Multifocal Invasive Lobular Breast Tumors

BACKGROUND: Invasive lobular carcinoma (ILC) comprises approximately ~10–20% of breast cancers. In general, multifocal/multicentric (MF/MC) breast cancer has been associated with an increased rate of regional lymph node metastases. Tumor heterogeneity between foci represents a largely unstudied sour...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Norton, Nadine, Advani, Pooja P., Serie, Daniel J., Geiger, Xochiquetzal J., Necela, Brian M., Axenfeld, Bianca C., Kachergus, Jennifer M., Feathers, Ryan W., Carr, Jennifer M., Crook, Julia E., Moreno-Aspitia, Alvaro, Anastasiadis, Panos Z., Perez, Edith A., Thompson, E. Aubrey
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831790/
https://ncbi.nlm.nih.gov/pubmed/27078887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153411
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