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Anti-bacterial flavonoids from medicinal plants covalently inactivate type III protein secretion substrates

Traditional Chinese Medicines (TCMs) have been historically used to treat bacterial infections. However, the molecules responsible for these anti-infective properties and their potential mechanisms of action have remained elusive. Using a high-throughput assay for type III protein secretion in Salmo...

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Foilsithe in:J Am Chem Soc
Main Authors: Tsou, Lun K., Lara-Tejero, María, RoseFigura, Jordan, Zhang, Zhenrun J., Wang, Yen-Chih, Yount, Jacob S., Lefebre, Matthew, Dossa, Paul D., Kato, Junya, Guan, Fulan, Lam, Wing, Cheng, Yung-Chi, Galán, Jorge E., Hang, Howard C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831573/
https://ncbi.nlm.nih.gov/pubmed/26847396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11575
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