The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis

BACKGROUND: Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogene-induced tumorigenesis to overcome these biologic obstacles. We employed compa...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Aprelikova, Olga, Chen, Kenny, El Touny, Lara H., Brignatz-Guittard, Constance, Han, Justin, Qiu, Tinghu, Yang, Howard H., Lee, Maxwell P., Zhu, Min, Green, Jeffrey E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831179/
https://ncbi.nlm.nih.gov/pubmed/27081402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0205-6
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