Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In primary T cells treated with exogenous Nef or acutely infected with Nef-expressing HIV-1 in vitro, Akt...

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Publicat a:Sci Rep
Autors principals: Kumar, Amit, Abbas, Wasim, Colin, Laurence, Khan, Kashif Aziz, Bouchat, Sophie, Varin, Audrey, Larbi, Anis, Gatot, Jean-Stéphane, Kabeya, Kabamba, Vanhulle, Caroline, Delacourt, Nadège, Pasquereau, Sébastien, Coquard, Laurie, Borch, Alexandra, König, Renate, Clumeck, Nathan, De Wit, Stephane, Rohr, Olivier, Rouzioux, Christine, Fulop, Tamas, Van Lint, Carine, Herbein, Georges
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831010/
https://ncbi.nlm.nih.gov/pubmed/27076174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24090
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