Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

Marfan syndrome (MFS) is an autosomal dominant genetic disease caused by abnormal formation of the extracellular matrix with an incidence of 1 in 3, 000 to 5, 000. Patients with Marfan syndrome experience poor quality of life caused by skeletal disorders such as scoliosis, and they are at high risk...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Umeyama, Kazuhiro, Watanabe, Kota, Watanabe, Masahito, Horiuchi, Keisuke, Nakano, Kazuaki, Kitashiro, Masateru, Matsunari, Hitomi, Kimura, Tokuhiro, Arima, Yoshimi, Sampetrean, Oltea, Nagaya, Masaki, Saito, Masahiro, Saya, Hideyuki, Kosaki, Kenjiro, Nagashima, Hiroshi, Matsumoto, Morio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830947/
https://ncbi.nlm.nih.gov/pubmed/27074716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24413
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